Product Description: Promethazine Hydrochloride and Codeine Phosphate Syrup CV

Description: 6.25 mg/10 mg per 5 mL Boysenberry Flavored Syrup

Compare To: Phenergan® with Codeine

Size: 473 mL

Type: Rx

Orange Book: AA

Storage: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light.

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What is codeine?

Codeine is a painkiller used to treat pain, for example, after an operation or an injury. Codeine is also used for long-standing pain when everyday painkillers, such as aspirin, ibuprofen, and paracetamol, haven’t worked.

Codeine is also used to treat diarrhea. THC oil cartridges shipped anywhere 

Codeine is available on prescription. It comes as tablets, a liquid to swallow, and an injection. Codeine injections are usually only given in hospitals.

You can buy lower-strength codeine from a pharmacy. It comes mixed with paracetamol (co-codamol), aspirin (co-codaprin), or ibuprofen (Nurofen Plus).

You can also buy codeine from a pharmacy as a syrup (linctus) to treat dry coughs.

2. Key facts About Codiene

  • Codeine works by stopping pain signals from traveling along the nerves to the brain.
  • The most common side effects of codeine are constipation, feeling sick (nausea), and feeling sleepy.
  • It’s possible to become addicted to codeine, but this is rare if you’re taking it to relieve pain and your doctor is reviewing your treatment regularly.
  • It may be best not to drink alcohol while taking codeine, as you’re more likely to get side effects like feeling sleepy.
  • Do not give codeine to children under 12 years old. Only give codeine to children aged 12 to 18 if everyday painkillers like paracetamol and ibuprofen haven’t worked.

3. Who can and can’t take codeine?

Codeine can be taken by adults and children aged 12 years and older.

Only give codeine to children (aged 12 to 18 years) if everyday painkillers such as paracetamol and ibuprofen haven’t worked.

Codeine is not suitable for some people. Tell your doctor before starting the medicine if you have:

  • had an allergic reaction to codeine or any other medicines in the past
  • a lung problem
  • a head injury
  • adrenal gland problems
  • an illness that causes seizures
  • an addiction to alcohol
  • an underactive thyroid gland
  • kidney or liver problems
  • gallstones
  • an enlarged prostate
  • low blood pressure
  • myasthenia gravis (a rare illness that causes muscle weakness)
  • symptoms of ulcerative colitis (a bowel condition)

Do not give codeine to children who are under 18 years old and have had their tonsils or adenoids removed because of a sleep problem called obstructive sleep apnea.

Codeine is not generally recommended during pregnancy. Tell your doctor before taking codeine if you’re trying to get pregnant, are already pregnant, or if you are breastfeeding.

4. How and when should I take Codiene?

It’s important to take codeine as your doctor has asked you to.

Take codeine with, or just after, a meal or snack, so it’s less likely to make you feel sick.

You can take codeine at any time of day, but try to take it at the same times every day and space your doses evenly.

Different types of codeine

Codeine comes as:

  • Tablets: these contain 15mg, 30mg, or 60mg of codeine
  • a liquid that you swallow; this contains 25mg of codeine in a 5ml spoonful
  • cough syrup: this contains 15mg of codeine in a 5ml spoonful
  • an injection (usually given in the hospital)

If you’re taking codeine as a liquid, it will come with a plastic spoon or syringe to help you measure the correct amount. Ask your pharmacist for one if you don’t have one. Do not measure the liquid with a kitchen teaspoon because it won’t give the right amount.

How much to take

The usual dose of codeine is 15mg to 60mg. You can take this dose up to four times a day.

For treating pain:

  • adults usually take one or two 30mg tablets every 4 hours
  • children (aged 12 to 18 years) usually take one or two 30mg tablets (or one or two 5ml spoonfuls of liquid) every 6 hours
  • elderly people or people with kidney or liver problems usually take a 15-mg tablet every 4 hours

For treating diarrhoea:

  • adults usually take one or two 30mg tablets (or one or two 5ml spoonfuls of liquid) every 4 hours
  • children (aged 12 to 18 years) usually take one or two 30mg tablets (or one or two 5ml spoonfuls of liquid) every 6 hours
  • elderly people or people with kidney or liver problems usually take a 15-mg tablet every 4 hours

For treating a cough:

Adults and children usually take one or two 5-ml spoonfuls of cough syrup every 4 to 6 hours.

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Chemical Formula
  • Codein
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  • Codéine
  • Codeine polistirex
  • Codeinum
  • Methylmorphine

    General Effects of Codeine

    Codeine is a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone. A small amount of ingested codeine is converted to morphine in the body. Codeine increases tolerance to pain, reducing existing discomfort. In addition to decreasing pain, codeine also causes sedation, drowsiness, and respiratory depression.

    Antitussive activity

    This drug has shown antitussive activity in clinical trials and has been effective in coughs secondary to tuberculosis and insomnia due to coughing. Codeine suppresses the cough reflex through a direct effect on the cough center in the medulla.

    Effects on intestinal motility

    Codeine may reduce intestinal motility through both a local and possibly central mechanism of action. This may lead to constipation. The chronic use of opioids, including codeine sulfate, may lead to obstructive bowel disease, particularly in patients with underlying disorders of intestinal motility.

    Effects on the central nervous system

    Codeine phosphate is an opioid analgesic with uses similar to those of morphine but much less potent as an analgesic. Its primary site of action is at the mu-opioid receptors distributed throughout the central nervous system. The sedative activities of codeine are less potent than those of morphine 13. Codeine may cause respiratory system depression by activating μ-opioid receptors at specific sites in the central nervous system.

    Codeine Effects on Blood Pressure

    This drug poses an increased risk of compromising the ability to maintain blood pressure due to peripheral vasodilation and other mechanisms. buy codeine online without prescription

    Effects on chronic cancer pain and other types of pain

    Codeine is an opioid analgesic with similar indications to those of morphine; however, it is much less potent in its pain-relieving properties. Its primary action takes place at the mu-opioid receptors, which are distributed throughout the central nervous system. The average duration of action is about 4 hours.

    Regular dosing of opioid analgesics such as codeine in patients with severe cancer pain has been well-documented to improve symptoms

Additional information


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